Allan Jordan;Klenke Burkhard;Karine Poullennec;Simon Bedford;Ian Yule
发明人:
Allan Jordan,Simon Bedford,Klenke Burkhard,Ian Yule,Karine Poullennec
申请号：
US12678376
公开号：
US08354415B2
申请日:
2008.09.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compounds of formula (I) are A2B wherein R1 and R2 are independently selected from hydrogen, or optionally substituted CrC6 alkyl, C1-C6alkoxy-(C1-C6)-alkyl, C3-C8 cycloalkyl, aryl, heteroaryl, aryl-(C1-C6)-alkyl, or heteroaryl-(C1-C6)-alkyl； or R−1 and R2 taken together with the nitrogen atom to which they are attached form an optionally substituted 5- or 6-membered ring； R3 and R4 are independently selected from hydrogen, or optionally substituted C1-C6 alkyl, C1-C6 alkoxy-(C1-C6)-alkyl, C3-C8 cycloalkyl, aryl, heteroaryl, aryl-(C1-C6)-alkyl, or heteroaryl-C1-C6)-alkyl； or R3 and R4 taken together with the nitrogen atom to which they are attached form an optionally substituted 5- or 6-membered ring； R5 and R6 are independently selected from hydrogen, C1-C6 alkyl, aryl, aryl-(C1-C6)-alkyl, —NHR7—N(—R8)—R9, —NH—(C═O)—R10, —(C═O)—NH—R11, —(C═O)—O—R12, or halo； and R7, R8, R9, R10, R−11, and R12 are independently selected from C1-C6 alkyl, aryl, aryl-(C1-C6)-alkyl and heteroaryl.
