ДИН Николас М. (US),КРОЧМЭЛ Линкольн (US),ХАРДИ Грегори (US),ФОУЛКЕС Дж. Гордон (US),О,ДОННЕЛЛ Найалл (US),ЯНГ Лерой (US),ДЖЕУЭЛЛ Марк (US)
申请号：
RU2013134403/15
公开号：
RU2013134403A
申请日:
2012.02.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of treating a keloid or preventing the formation, re-formation or growth of a keloid after skin damage in a subject in need thereof, comprising administering to the subject, at the site of a keloid or skin damage, one or more injections of a composition comprising a modified oligonucleotide consisting of 12-30 bound nucleosides, at least part of the sequence of which of 12 nucleotide bases is present in the region selected from nucleotides 553-611, 718-751, 1388-1423, 1457-1689, 2040-2069, 2120-2147, 2728-2797, 2267- 2301, 1394-1423, 1469-1508, 1559-1605, 1659-16 89, 2100-2129 and 1399-1423 of SEQ ID NO: 9, or a salt or ester thereof, in an amount effective to treat or prevent the formation, re-formation or growth of a keloid, wherein the effective amount is from 0.1 to 50 mg of the modified oligonucleotide per injection per linear centimeter of keloid or skin damage. 2. A method of treating a hypertrophic scar or preventing the formation, re-formation or growth of a hypertrophic scar after skin damage in a subject in need thereof, comprising administering to the subject, at the site of a hypertrophic scar or skin damage, one or more injections of a composition containing a modified oligonucleotide consisting of 12- 30 linked nucleosides, at least a portion of the sequence of which of 12 nucleotide bases is present in a region selected from nucleotides 553-611, 718-751, 1388-1423, 1457- 1689, 2040-2069, 2120-2147, 2728-2797, 2267-2301, 1394-1423, 1469-1508, 1559-1605, 1659-1689, 2100-2129 and 1399-1423 SEQ ID NO: 9, or a salt thereof or ether in an amount effective to treat or to prevent the formation, re-formation or growth of a hypertrophic scar, where1. Способ лечения келоида или предотвращения образования, повторного образования или роста келоида после повреждения кожи у субъекта, нуждающегося в этом, включающий проведение субъекту, в месте келоида или повреждения кожи, одной или более инъекций композиции, содержащей модифицированный олигонуклеотид,
