WENDEL, HANS-GUIDO,WOLFE, ANDREW,SINGH, KAMINI,ZHONG, YI,DREWE, PHILLIP,RATSCH, GUNNAR
申请号：
CA2932422
公开号：
CA2932422A1
申请日:
2014.12.05
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Methods are provided for identifying agents capable of modulating cap-dependent RNA translation by comparing translation efficiency in the presence and absence of the agent in an in-vitro or in-vivo translation system that comprises eIF4A and an mRNA having one or more eIF4A-dependent translation-controlling motifs. The modulation of translation in the presence of the agent indicates the agent as capable of modulating cap-dependent mRNA translation. The method can be used to identify anti-cancer agents and oncogenes that may be responsible for tumorigenesis.
