Luigi Aurisicchio,Gennaro Ciliberto,Rita Mancini,Emanuele Marra,Guiseppe Roscilli
申请号：
US15610740
公开号：
US20170342123A1
申请日:
2017.06.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More specifically, the invention concerns anti-tumor vaccines based upon plasmid DNA and/or genetic vectors carrying a codon-usage optimized sequence and coding for a mutant form of the ErbB-3 receptor. Furthermore, the invention refers to monoclonal antibodies directed against the ErbB-3 receptor, obtained using these methods and capable to block its activity in cancer cells.
