PROBLEM TO BE SOLVED: To provide a resveratrol derivative that generates hydrogen and exhibits keratin producing action, which is useful as a cosmetic, a food preparation, and a medicine, and which is, especially when used in cosmetic, expected to improve degradation of sebum, moisture holding power of skin, and resilience of skin, and to provide a method for producing the derivative.SOLUTION: Provided is a resveratrol derivative having a structure represented by the following formula (1) where four molecules of resveratrol are bonded, the resveratrol being obtained by subjecting a fermentation liquid to a protease treatment, followed by separation and purification by an ion exchange resin and the like, the fermentation liquid being obtained by adding Bacillus natto and Monascus purpureus to sprout-containing grape seeds and soybean powder and fermenting the mixture.EFFECT: The resveratrol derivative shows an amphiphilic property including hydrophobicity inside the molecule and hydrophilicity outside the molecule. The hydroxy group at 4-position of each resveratrol is free, and these hydroxy groups generate hydrogen, reduces cells, passes through cell membranes, activates genes of a keratin generating enzyme to increase production of keratin, suppresses decomposition of keratin, and activates proliferation of epithelial cells.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】化粧料、食品製剤、医薬品として有用であり、特に、化粧料に利用した場合、皮脂の分解、皮膚の水分保持力、皮膚の弾力の改善が期待される、水素を発生しケラチン産生作用を呈するレスベラトロール誘導体及びその製造方法の提供。【解決手段】ブドウの種子の新芽及び大豆粉末に納豆菌とベニコウジ菌を添加して発酵させた発酵液をプロテアーゼ処理し、イオン交換樹脂等で分離・精製することにより得られるレスベラトロールの4分子を結合した構造を呈する下式(1)で示されるレスベラトロール誘導体。【効果】前記レスベラトロール誘導体は、分子内は疎水性であり外部は親水性の両親媒性を示し、各々のレスベラトロールの4位の水酸基はフリーであり、この水酸基が水素を発生させ、細胞を還元し、細胞膜を通過し、ケラチン生成酵素の遺伝子を活性化してケラチン産生を増加させ、ケラチンの分解を抑制し、上皮細胞の細胞の増殖を活性化する。【選択図】なし
