Polymorphic form of 5-chloro-n-{ [(5s)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxa-zolidin-5-yl]-methyl} thiophene-2-carboxamide

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专利权人:

APOTEX PHARMACHEM INC

发明人:

WEERATUNGA GAMINI,BODHURI PRABHUDAS

申请号：

NZ59381809

公开号：

NZ593818A

申请日:

2009.12.31

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

593818 Disclosed is a polymorph of rivaroxaban (5-Chloro-N-{ [(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxa-zolidin-5-yl]-methyl} thiophene-2-carboxamide) which is shown in formula (I). The polymorph is characterised by an x-ray powder diffraction (XRPD) peak at 39.12 2 degrees theta and a differential scanning calorimetry (DSC) thermogram (scan rate 10 deg.C/minute) exhibiting a peak endotherm at an onset temperature of about 166°C and a peak maximum at about 183°C.

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