Memorial Sloan Kettering Cancer Center;Cornell University
发明人:
Michelle S. Bradbury,Ulrich Wiesner,Michael Overholtzer,Howard Scher,Kai Ma
申请号：
US16902577
公开号：
US20200316219A1
申请日:
2020.06.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.
