Devices and methods are provided for positioning a tool. In one embodiment, an endoscopic rotation device is provided having a rotatable collet, a flexible elongate translating mechanism, and an actuating mechanism. The rotatable collet can be configured to receive and engage a tool disposed therethrough, and the translating mechanism can be coupled to the collet. The actuating mechanism can be operatively associated with the translating mechanism and can be effective to cause the translating mechanism to apply a rotational force to the collet to rotate the tool disposed therethrough.
