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COMPOSES DE PYRROLOTRIAZINE ET PROCEDES D'INHIBITION DE KINASES TAM
专利权人:
INC.;SYROS PHARMACEUTICALS
发明人:
MOEBIUS, DAVID,MARINEAU, JASON J.,ZHANG, YI,AUSTGEN, KATHRYN,CHUAQUI, CLAUDIO EDMUNDO,MALOJCIC, GORAN,SINKO, WILLIAM,GUAN, HUIPING AMY,SAVOIE, TRACEY LODIE,CIBLAT, STEPHANE,JAMES, CLINT,XOLIN, AMANDIN
申请号:
CA3078942
公开号:
CA3078942A1
申请日:
2018.10.09
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat cancer. (II), or a pharmaceutically acceptable salt thereof, wherein: R1 is pyridin-3-yl, pyridin-4-yl, pyrazol-4-yl, cyclohexyl, or 8-azabicyclo[3.2.1]oct-2- ene-3-yl, wherein R1 is optionally substituted with up to four independently selected substituents; R2 is cyclohexyl substituted with hydroxy and optionally substituted with one or two additional substituents independently selected from C1-C4 alkyl and fluoro, or is 4,5,6,7- tetrahydro-lH-indazolyl optionally substituted with one to three substituents independently selected from C1-C4 alkyl and fluoro; and R3 is -C3-C8 alkyl, -(C2-C6 alkylene)-0-(C1-C6 alkyl), C3-C6 cycloalkyl, or -(C2-C6 alkylene)-C3-C6 cycloalkyl, wherein R3 is optionally substituted with 1-5 substituents inde endentl selected from deuterium, halo, and -OH.
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