A parameter generation system to determine parameters of a diagnostic injection protocol having at least one admixture phase in which an admixture inclusive of a pharmaceutical having a contrast enhancement agent and a diluent is injected into a patient, the parameter generation system comprising: an algorithm for determining an initial ratio of the pharmaceutical to the diluent in the at least one admixture phase for the patient using information comprising a patient parameter available without performing a characterization of a cardiovascular system of the patient via a test bolus of the pharmaceutical, wherein the parameter of the patient is at least one of weight, body mass index, body surface area and cardiac output of the patient.