ZHANGJIAGANG INSTITUTE OF INDUSTRIAL TECHNOLOGIES SOOCHOW UNIVERSITY
发明人:
CHEN, Xihua,CHEN, Rongxiang,WAN, Xiaobing
申请号：
WO2017CN80974
公开号：
WO2018191871(A1)
申请日:
2017.04.18
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
Disclosed in the present invention is a method for use in preparing an isoxazoline derivative: an olefin derivative, a diazo derivative and tert-Butyl nitrite are used as a reaction substrate, while a copper compound is used as a catalyst; under alkaline conditions, a tandem cyclization reaction is further carried out by means of the coupling of metal carbene and free radicals so as to obtain an isoxazoline derivative. The present invention designs mild reaction conditions, and the raw materials selected are low-cost and easy to obtain, an inexpensive metal copper compound being selected as a catalyst, while the isoxazoline derivative may be conveniently synthesized directly in a sealed tubular system. The present invention avoids the use of a large amount of an oxidant, the use of a noble metal as a catalyst and the harsh water-free and oxygen-free experimental conditions of a traditional method for synthesis such that the reaction is simple and easy, while post-processing is simple, thereby having potential
