University of Pittsburgh- Of the Commonwealth System of Higher Education;Massachusetts Institute of Technology
发明人:
Steven R. Little
申请号：
US15674128
公开号：
US20180021260A1
申请日:
2017.08.10
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (Treg cells) with immunosuppressive capabilities. A therapeutically relevant platform comprising artificial constructs are contemplated comprising numerous soluble and surface bound Treg cell stimulating factors that may induce tolerance following allograft transplantation. Such artificial constructs, being the size of a cell, have surface bound monoclonal antibodies specific to regulatory T-cell surface moieties and encapsulated soluble regulatory T-cell modulating factors.
