The compound of formula (I) or Qi Li Body Iso Agencies Body,On mutual Change Iso Agencies Body Huo Drug Learn Ke receive Which,Or molten Elixirs compound or preceding Drug,Wherein R1,R2,Ra,Rb,Rc,Rd,X,Ring B and Ring C such as this Wen Suoding Righteousness,And and Qi Zhong Ring B and NH-C (=X)-NH part be in trans- Agencies type,For the inhibition Elixirs And of TrkA kinases Treatment can be controlled with what can control the disease of Treatment with TrkA kinase inhibition Elixirs Jin row,Zhu such as pain,Cancer,Inflammation/inflammatory disease,Refreshing The Change disease,Certain infectious diseases,This Jaeger LunShi Integrated conjunction disease,Iso diseases of sub- Palace Inner film,Diabetic keratopathy week Wai mind The disease Change,Prostatitis or pelvis Teng Tong Integrated close disease.式(I)的化合物或其立體異構體、互變異構體或藥學上可接受的鹽、或溶劑化物或前藥，其中R1、R2、Ra、Rb、Rc、Rd、X、環B和環C如本文所定義，並且其中環B和NH‑C(＝X)‑NH部分呈反式構型，爲TrkA激酶的抑制劑並可用於治療可用TrkA激酶抑制劑進行治療的疾病，諸如疼痛、癌症、炎症／炎性疾病、神經變性疾病、某些感染性疾病、斯耶格倫氏綜合症、子宮內膜異位症、糖尿病性周圍神經病變、前列腺炎或骨盆疼痛綜合症。
