It also provides antibodies that specifically bind to TDP-43 protein abnormality aggregates invention, TDP-43 Puroteinopachi lesions containing said antibodies, detection agents, TDP-43 Puroteinopachi lesions, and using the antibodies I will provide a diagnostic method or a method of detecting.本発明は、TDP-43蛋白異常凝集物に特異的に結合する抗体を提供し、また、当該抗体を含有する、TDP-43プロテイノパチー病変の検出薬、及び当該抗体を用いたTDP-43プロテイノパチー病変の検出方法又は診断方法等を提供する。