The present invention relates to influenza vaccine formulations andvaccination regimes for immunising against influenza disease, their use inmedicine, in particular their use in augmenting immune responses to variousantigens, and to methods of preparation. In particular, the invention relatesto multivalent influenza immunogenic compositions comprising an influenzaantigen or antigenic preparation thereof from at least two influenza virusstrains, at least one strain being associated with a pandemic outbreak orhaving the potential to be associated with a pandemic outbreak, in combinationwith an oil-in-water emulsion adjuvant.
