INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASCANCER CENTER;UNIVERSITAT POMPEU FABRA;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
The present disclosure provides methods of determining the risk of a subjecthaving or developing a cancer or autoimmunedisorder based on the affinity of the subjects MHC-I alleles for oncogenicmutations or peptides linked with autoimmune disorders,methods for improving cancer diagnosis, and kits comprising agents that detectthe oncogenic mutations in a subject.