A toothbrush holder enclosure is provided which includes: a back plate, a resilient clamp, a front cover and a sanitation agent dispenser. The back plate and front cover form a housing. The clamp is made of a resilient material giving it a springy property and shaped to urge two clamp arms towards one another in order for the clamp to grip a toothbrush. Two rollers at the tips of the clamp arms engage a toothbrush head inserted in the clamp as the clamp is spread apart from the clamped position to a deviated state. With the toothbrush inserted, the rollers exert pressure on a neck of the toothbrush to hold the toothbrush fast in place with bristles generally oriented and generally aligned with a dispensing orifice supplied with sanitation agent from a reservoir of the dispenser. An actuator causes sanitation agent to issue from the dispensing orifice.
