Camsylate salt of (1r,1R,4R)- 4-methoxy-5"-methyl-6-[5-(prop-1-yn-1-yl)pyridin- 3-yl]-3H-dispiro[cyclohexane-1,2-inden-12-imidazole]-4"-amine and crystalline forms thereof for the treatment of A[beta]-related pathologies such as e.g. Alzheimers disease
BOHLIN MARTIN HANS,BOHLIN MARTIN HANS,STEWART CRAIG ROBERT,STEWART CRAIG ROBERT
申请号：
PL13733415
公开号：
PL2864316T3
申请日:
2013.06.20
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
A process for the preparation of a camsylate salt ((1S)-(+)-10 camphorsulfonic acid) of (1r,1R,4R)- 4-methoxy-5"-methyl-6-[5-(prop-1-yn-1-yl)pyridin- 3-yl]-3H-dispiro[cyclohexane-1,2-inden-12-imidazole]-4"-amine is disclosed as well as pharmaceutical compositions containing the salt and therapeutic uses of the salt for treating A²-related pathologies such as Alzheimers Disease, Downs Syndrome, ²-amyloid angiopathy and conditions such as dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinsons Disease, progressive supranuclear palsy or cortical basal degeneration.
