The present disclosure is related to a method for scattering correction of an image. The method may include obtaining an image of a subject and a reference image of air. The method may also include identifying an OOI from the image, the OOI including one or more pixels. For each pixel of the one or more pixels of the OOI, the method may also include determining an equivalent thickness of the OOI corresponding to the each pixel based on a pixel value of the each pixel and the reference image, and determining a scatter correction coefficient of the each pixel based at least in part on the equivalent thickness of the OOI corresponding to the each pixel. The method may further include correcting the pixel value of the each pixel using the corresponding scatter correction coefficient for each pixel of the one or more pixels of the OOI.
