DELUCA, HECTOR F.,GRZYWACZ, PAWEL,PLUM, LORI A.,CLAGETT-DAME, MARGARET
申请号：
CA2776462
公开号：
CA2776462C
申请日:
2010.09.30
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
This invention discloses (20S .22E)-2-methylene-19-nor-22-enc-1.alpha.,25 -dihydroxyvitaminD3 analogs of general formula I, and specifically (20S,22E)-2-methylene-19-nor-22-ene-1.alpha.,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. Thiscompound exhibitssignificant vitamin D receptor binding activity and transcription activity aswell aspronounced activity in arresting the proliferation of undifferentiated cellsand inducingtheir differentiation to the monocyte thus evidencing use as an anti-canceragent, especiallyfor the treatment or prevention of leukemia, colon cancer, breast cancer, skincancer orprostate cancer.(see formula I)
