This invention discloses a bio-degenerable bone cement and a manufacturing method of producing the bio-degenerable bone cement. The bio-degenerable bone cement is made of a mixture of poly (propylene fumarate) (PPF) and a diphasic material of tetra-calcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA). The bone cement produced by the manufacturing method of the invention is injectable, bio-degenerable and non-penetrable to radioactive rays and features the advantages of a compressive strength close to the strength of bones, a low polymerization temperature, and a high biological compatibility.