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VARIANT FLAVIVIRUS ENVELOPE SEQUENCES AND USES THEREOF
专利权人:
Excivion Ltd.
发明人:
Peter LAING
申请号:
US16303588
公开号:
US20190300580A1
申请日:
2017.05.22
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention relates to isolated recombinant analogues of flavivirus E-protein fusion loops comprising at least one glycosylation site for an N-linked glycan that is not present in the natural flavivirus E-protein fusion loop sequence, wherein the at least one glycosylation site is an N-linked glycosylation sequon (Asn-X-Ser/Thr) and the Asn (N) residue of the sequon occupies any of positions 98-110 (DRGWGNGCGLFGK) of the natural flavivirus E-protein fusion loop amino acid sequence, wherein X is any amino acid residue except proline and Ser/Thr denotes a serine or threonine residue.
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