A fixation device (1) for retaining a skin penetrating medical device (2), such as a cannula, on the skin of a patient, said fixation device (1) comprising a retaining component (3) including a support layer (4) having an adhesive coating (5), said fixation device further comprising a landing zone component (6), including a support layer (7) having an adhesive coating (8), said landing zone component (6) being adapted to be adhesively attached to the skin around the point of penetration (10), and said retaining component (3) acting as a skin-contacting component and being adapted to be applied on top of the landing zone component (6), and at least partially covering the skin penetrating medical device (2), such that the adhesive coating (5) of the retaining component (3) is applied to the support layer (7) of the landing zone component (6), the adhesive coating (5) of the retaining component (3) comprising a first adhesive, and the adhesive coating (8) of the landing zone component (6)comprising a second adhesive, said first adhesive being different from said second adhesive.
