Furet, Pascal,Grotzfeld, Robert Martin,Jahnke, Wolfgang,Jones, Darryl Brynley,Manley, Paul,Marzinzik, Andreas,Pelle, Xavier Francois Andre,Salem, Bahaa,Schoepfer, Joseph,Spieser, Erich Alois
申请号:
AU2013261128
公开号:
AU2013261128B2
申请日:
2013.05.09
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.