KNOCKOUT MOUSE, SCREENING METHOD FOR MATERIAL TO SUPPRESS MEDIAL TEMPORAL LOBE EPILEPSY, AND SELECTION METHOD FOR TECHNIQUE TO SUPPRESS MEDIAL TEMPORAL LOBE EPILEPSY
PROBLEM TO BE SOLVED: To provide a knockout mouse used for screening a material and/or a technique to suppress medial temporal lobe epilepsy.SOLUTION: There is provided a knockout mouse used for screening a material and/or a technique to suppress medial temporal lobe epilepsy in which the function of the Girdin gene is lost, and which exhibits phenotypes of (1) to (3): (1) hippocampal sclerosis is seen, (2) brain damage other than the damage to the hippocampus is limited, and (3) spontaneous epilepsy which can be said to have originated from the hippocampus is seen.SELECTED DRAWING: Figure 6【課題】内側側頭葉てんかんを抑制する物質及び／又は手法をスクリーニングするために用いられるノックアウトマウスの提供。【解決手段】Ｇｉｒｄｉｎ遺伝子の機能が失われ、且つ、以下の（１）～（３）の表現型を示す内側側頭葉てんかんを抑制する物質及び／又は手法をスクリーニングするために用いられるノックアウトマウス。（１）海馬硬化をもつこと。（２）海馬外の脳損傷が限定的であること。（３）海馬起源といえる自発的なてんかんがあること。【選択図】図６
