BROWN, Matthew Frank,CASIMIRO-GARCIA, Agustin,CHE, Ye,COE, Jotham Wadsworth,FLANAGAN, Mark Edward,GILBERT, Adam Matthew,HAYWARD, Matthew Merrill,LANGILLE, Jonathan David,MONTGOMERY, Justin Ian,TELLIEZ
申请号：
ES14816404
公开号：
ES2654051T3
申请日:
2014.11.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having the structure: ** (See formula) ** or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer or diastereomer thereof, and wherein R2 is selected from the group consisting of hydrogen, deuterium, C1-C6 straight or branched chain alkyl, C3-C6 cycloalkyl, C6-C10 aryl, monocyclic or bicyclic heteroaryl, comprising 5 and / or 6 membered rings, straight or branched chain alkyl (aryl) C1-C6, ( heteroaryl) straight or branched chain C1-C6 alkyl, (heterocyclic) straight or branched chain C1-C6 alkyl, (straight or straight chain C1-C6 alkyl) aryl, (straight or straight chain C1-C6 alkyl) heteroaryl , (straight or branched chain C1-C6 alkyl) heterocyclic, straight or branched chain C1-C6 perfluoroalkyl, straight or straight chain C1-C6 alkoxy, straight or branched C1-C6 perfluoroalkoxy, halogen, cyano, hydroxyl, amino, carboxy, aminocarbonyl, (straight chain C1-C6 alkyl or ra mified) aminocarbonylamino, (C1-C6 straight or branched chain alkyl) aminocarbonyl, -SOR12, -SO2R12, -NR13SO2R12, -SO2NR13R14 and -NR13SO2NR14R15； wherein said alkyl, aryl and heteroaryl is independently optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, cyano, alkylamino, dialkylamino, CF3, aminocarbonyl, (C1-C6 alkyl chain linear or branched) aminocarbonyl and C3-C6 cycloalkyl； R3 is selected from the group consisting of hydrogen, deuterium, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain perfluoroalkyl, halogen and cyano； A is - (CRaRb) q- (CRcRd) r-, in which Ra, Rb, Rc and Rd are independently selected from hydrogen, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain perfluoroalkyl, C6-C10 aryl, monocyclic or bicyclic heteroaryl, comprising 5 and / or 6-membered rings, alkylaryl, (aryl) C1-C6 straight or branched chain alkyl, (heteroaryl) C1-C6 straight or branched chain alkyl, halogen , cyano, hydroxy, C1-C6 straight or branched chain alkoxy, amino,
