Provided herein are robotic or automated multimodal tissue scanning or imaging systems and methods. The systems comprise a robotic delivery device configured to mechanically scan one or more zones of a tissue by co-registering at least two modalities, i.e., one or more of each of a sensor modality and an imaging modality and acquiring sensor modality data at one or more positions in the zone(s) as the sensor modality is dimensionally translated along the device axes. The system also comprises a computational core of a plurality of interlinked modules for planning, processing, tissue-sampling, visualization, fusion, and control of the delivery device and the system. The methods provided herein utilize the automated systems to produce spatial maps based on the analyzed sensor modality data.
