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CRYSTAL POLYMORPHISM OF KCNQ2-5 CHANNEL ACTIVATOR
专利权人:
LTD.;ONO PHARMACEUTICAL CO.
发明人:
YASHIRO, Kentaro,KIJIMA, Hideomi,WAKAMATSU, Daisuke,SAITO, Tetsuji
申请号:
SG11201809184V
公开号:
SG11201809184VA
申请日:
2017.04.21
申请国别(地区):
SG
年份:
2018
代理人:
摘要:
Crystal polymorphism may exist in a crystalline compound. In the case where crystal polymorphism exists, depending on the crystal form, solubility, dissolution rate, 5 stability against heat, light, humidity, etc. or the like is different. Accordingly, in the production of a pharmaceutical product, it is a very important task to select a crystal form of a drug substance most suitable for a disease indication and a dosage form. The present invention relates to novel crystal forms (A crystal, W crystal, and a hydrate crystal (H crystal)) of a compound I having a strong opening action with respect to 10 KCNQ2-5 channels.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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