The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.本發明係關於新穎之式I哌啶基-二氫噻吩并嘧啶亞碸其中環A係可視情況包含一或二個氮原子之6員芳環,及其中R為Cl,及其中R可位於環A之對位、間位或鄰位,其中S*係代表對掌性中心之硫原子,且係關於其所有醫藥上可接受之鹽、對映異構物及消旋物、水合物及溶劑化物,及該等化合物於治療呼吸道之發炎性疾病或過敏性疾病(諸如COPD或氣喘)的用途。