1. Sigma ligand for use in the prevention and / or treatment of pain in bone cancer. 2. The sigma ligand according to claim 1, where the pain is selected from acute and / or chronic pain resulting from bone cancer, mainly such as neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathy, neuritis or neuropathy against the background of surgical interventions. 3. The sigma ligand according to claim 1 or 2, which is selected from a sigma receptor antagonist, preferably selected from a neutral antagonist, an inverse agonist, or a partial antagonist. The sigma ligand according to claim 1 or 2, having the general formula (I): wherein R is selected from the group consisting of: hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl , substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl, -COR, -C (O) OR, -C (O) NRR, -CH = NR, -CN, -OR, -OC (O ) R, -S (O) -R, -NRR, -NRC (O) R, -NO, -N = CRR and halogen； R are selected from the group consisting of: hydrogen substituted, unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl, -COR, -C (O) OR -C (O) NRR, -CH = NR, -CN, -OR, -OC (O) R, -S (O) -R, -NRR, -NRC (O) R, -NO, -N = CRR halogen； R and R are independently selected from the group consisting of: hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted1. Сигма-лиганд для применения в профилактике и/или лечении боли при раке костей.2. Сигма-лиганд по п.1, где боль выбирают из острой и/или хронической боли, разви
