Patient-specific instruments for preparing bones, such as a proximal femur and an acetabulum in a total hip arthroplasty, to receive respective orthopedic prostheses. The guides include a femoral resection guide and a bone canal preparation guide, each having a surface conforming to at least one of a metaphysis and a femoral neck of a femur. The femoral resection guide includes a cut referencing surface to guide a cutting instrument, and the bone canal preparation guide includes a guide aperture sized to guide a rasping instrument. An acetabular guide includes a surface conforming to an acetabulum and a guide aperture for guiding a surgical instrument such as a reaming instrument. The patient-specific, conforming surfaces of each of the guides may be designed based on patient-specific anatomical data obtained from the use of imaging technology.
