An imaging system captures images of a human submental profile in a dimension controlled environment and utilizes image analysis algorithms for detecting submental changes. Instead of implementing a strict posture control of a subject, the imaging system allows the subject to freely move his/her head in an up-and-down direction and a high speed camera captures this movement through a series of images at varying head-to-shoulder angles. The image analysis algorithms may accurately compare before and after images at similar head-to-shoulder angles to identify changes in a human submental profile using a series of measurements and checkpoints.