The invention relates to systems and methods for measuring the angular accessibility limitations of the anterior angle of the eye, targeting one or multiple treatment zones within the anterior angle area of the eye and delivering highly focused photodisruptive laser pulses with pulse durations <;50 picoseconds creating channels into various anatomical structures within the anterior angle of the eye. The invention further includes custom gonioscopy lens systems, patient interface systems and a laser delivery system to deliver highly focused laser beams to the anterior angle area of the eye.