An ultrasonic diagnostic imaging system scans a volumetric region of a body. A clinician defines a three dimensional region of interest within the volumetric region. The three dimensional region of interest is viewed from two different viewing directions to give the clinician a sense of the structure, makeup, and orientation of the region of interest. The three dimensional region of interest can be viewed from viewing directions in 180° opposition to each other, orthogonal, or at an intermediate angle. Manipulation of one view of the three dimensional region of interest causes both views to change, as if the clinician were manipulating both views simultaneously in the same way.