Heterobicyclo-substituted compounds- [1,2,4] triazolo [1,5-c] quinazolin-5-amine suitable for the treatment or prevention of central nervous system disorders
compound of Formula GI: *** Formula ** or a pharmaceutically acceptable salt thereof, in which: W is nitrogen or carbon； m is 1, 2, 3 or 4； n is an integer from 0 to 4, where the sum of n + m is at least 2 to 4, and where, when W is N, m is at least 2； Gd1 to Gd4 are independently hydrogen or a C1-6 alkyl； p is 1 or 2； X, Y and Z together with W and the carbon to which X and W are linked form an aromatic or heteroaromatic moiety of 5 to 6 members, and are independently: (a) - (RG1) C>； =, in which RG1 is : (i) hydrogen； (ii) C1-8 alkyl, optionally substituted with one or more halogen atoms； (iii) -C (O) -C 1-8 alkyl； (iv) -CN； (v) -S-C1-8 alkyl； (vi) -O-C1-6 alkyl； (vii) - (CH2) q1- (C>； = O) q2-N (R2) 2, where R2 25 is independently each time hydrogen appears, C1-6 alkyl or heteroaryl, and where q1 is 0 or 1 and q2 is 0 or 1； (viii) -C (O) O-C1-8 alkyl； (ix) halogen； (x) a mono or polycyclic heterocyclic moiety comprising up to 10 carbon atoms and one or more heteroatoms selected from N, S or O, optionally substituted with one or more C1-6 alkyl, morpholino, phenyl (optionally substituted with halogen), heteroaryl or halogen； (xi) aryl, which is optionally substituted with one or more substituents that are: (1) halogen； or (2) C1-6 alkyl which is optionally substituted with one or more halogen atoms； (xii) -NH-C (O) -R3, wherein R3 is C1-6 alkyl or heteroaryl； or (xiii) heteroaryl, which is optionally substituted with C1-6 alkyl (which is optionally substituted with one or more halogen atoms) or amino； or (b)>； NRG2, in which RG2 is: (i) hydrogen； (ii) C1-8 alkyl； or (iii) an aromatic moiety of up to 10 carbon atoms； (c) -N>； =； (d) -O-； or (e) -S-； and RG3 is a remainder of the structure: ** Formula ** in which: t is 0, 1 or 2； RG5 and RG6 are independently each time they appear: (a) H； (b) C1-10 alkyl, optionally substituted with one or more fluorine atoms； or (c) RG5 and RG6 taken together form a carbonyl moiety (C>； = O), with the proviso that if t>
