The present invention relates to a medicament delivery device comprising a generally elongated housing (10, 24), having a proximal and a distal end, a medicament delivery actuation mechanism (16), capable upon activation, of delivering doses of medicament from a medicament container (18), arranged with a medicament delivery member (20) and placed in said housing, a medicament delivery member shield (22) arranged to said medicament delivery member (20), a medicament delivery member guard (54) arranged movable in the proximal end of said housing (10, 24), wherein said medicament delivery member guard (54) is operably connected to said medicament delivery actuation mechanism (16), a protective cap (42) releasibly arranged to said proximal end of said housing, said protective cap (42) being provided with a medicament delivery member shield remover (50). The invention is characterised by a blocking element (58) arranged to said medicament delivery member guard (54); that said blocking element (58) is arranged movable between a blocking position and a release position, that said blocking element (58) is arranged with an engagement surface (62) arranged to engage with a proximal area (68) of said housing; that said blocking element (58) is arranged to engage with a surface of said medicament delivery member shield remover (50), retaining said blocking element (58) in said blocking position, wherein engagement of said engagement surface (62) with said proximal area (68) causes a blocking of said medicament delivery member guard (54) from movement, and wherein removal of said protective cap (42) and said medicament delivery member shield remover (50) enables a movement of said blocking element (58) to a release position when said engagement surface (62) engages said proximal area (68), allowing said medicament delivery member guard (54) to move.La présente invention concerne un dispositif d'administration de médicament comprenant un logement généralement allongé (10, 24), pr