Chemical embolization therapy combined with the therapeutic effect of peripheral arterial occlusion and local administration of anticancer drug is described in this specification. A particle or particulate occludes an artery that provides blood flow to the tumor and results in tumor hypoxia. Antiangiogenic agents are anticancer agents as described herein.末梢動脈閉塞の治療効果と抗がん剤の局所投与とを組み合わせた化学塞栓療法が本明細書に記載される。ある粒子若しくは微粒子が、腫瘍に血流を提供する動脈を閉塞させ、腫瘍酸素欠乏をもたらす。抗血管新生薬は、本明細書に記載のような抗がん薬である。