An oxygen-generating wound dressing is provided. The oxygen-generating wound dressing comprises a housing and a wound contacting layer. The interior of the housing comprises a barrier member to divide the housing into a reactant receptacle and a wound contacting layer receptacle. The reactant receptacle of the housing further comprises a first reactant receptacle, a second reactant receptacle, a check valve disposed between the first reactant receptacle and the second reactant receptacle, a flow regulating device disposed on the second reactant receptacle and a gas deliver tube for fluidly communicating the first reactant receptacle and the wound contacting layer receptacle. The entrance speed of the second reactant into the first reactant receptacle can be controlled by the flow regulating device. The oxygen partial pressure can be maintained preferably and the wound healing can be improved by using the oxygen-generating wound dressing of the present invention.
