Sudhir Agrawal,Wayne Jiang,Daqing Wang,Jessica Seitzer,Fu-Gang Zhu,Xianzhi Mao
申请号：
US15053309
公开号：
US20160251652A1
申请日:
2016.02.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed to compounds, compositions, and methods useful for modulating PD1, PDL1, IDO1, LAG3, TIM3, CTLA4, IDO2, CEACAM1, OX40, and/or OX40L mRNA or protein expression using gene silencing compounds comprising two or more single stranded antisense oligonucleotides that are linked through their 5′-ends to allow the presence of two or more accessible 3′-ends.
