Yvonne M. CHEN,Eugene Yu-Chuan CHIANG,Jane Louise GROGAN,Simon-Peter WILLIAMS,Matthew Lawrence ALBERT
申请号：
US16788003
公开号：
US20200172620A1
申请日:
2020.02.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.
