THE PRESET INVENTION PROVIDES A COMBINATION PHARMACEUTICAL COMPOSITION COMPRISING A) AN ACTIVATED-POTENTIATED FORM OF AN ANTIBODY TO A S-100 PROTEIN, B) AN ACTIVATED-POTENTIATED FORM OF AN ANTIBODY TO HISTAMINE, AND C) AN ACTIVATED-POTENTIATED FORM OF AN ANTIBODY TO TNF-ALPHA. VARIOUS EMBODIMENTS AND VARIANTS ARE PROVIDED. THE PRESENT INVENTION PROVIDES A METHOD OF TREATING A DISEASE OR CONDITION OF FUNCTIONAL ETIOLOGY OF THE GASTROINTESTINAL TRACT, SAID METHOD COMPRISING ADMINISTERING TO A PATIENT IN NEED THEREOF A COMBINATION PHARMACEUTICAL COMPOSITION COMPRISING A) AN ACTIVATED-POTENTIATED FORM OF AN ANTIBODY TO A HISTAMINE, B) AN ACTIVATED-POTENTIATED FORM OF AN ANTIBODY TO S-100 PROTEIN AND C) AN ACTIVATED-POTENTIATED FORM OF AN ANTIBODY TO TNF-ALPHA. VARIOUS EMBODIMENTS AND VARIANTS ARE PROVIDED. (NO SUITABLE FIGURE)