Low acidic species compositions and methods for producing and using the same using displacement chromatography

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专利权人:

发明人:

Chen Wang,Germano Coppola,Chris Chumsae

申请号：

US14079076

公开号：

US09017687B1

申请日:

2013.11.13

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods for producing such low AR compositions using displacement chromatography. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.

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