The present invention provides a tacrolimus containingointment having low dermal irritation and excellentstability. It wasfound that an ointment comprisingtriacetin as a solubilizer for tacrolimus may sufficientlysolubilize tacrolimus, has low dermal irritation andexcellent stability.Preferably, the ointment of thepresent invention is an o/o type (oil-in-oil type) ointmentin which tacrolimus-solubilized triacetin droplets aredispersed in an ointment base, preferably a mixture ofbeeswax and petrolatum.
