An exemplary method of predicting an amyloidosis status involves obtaining a profile of drusen in a periphery of a retina of a subject and using the profile to predict an amyloidosis status. Another exemplary method of predicting an amyloidosis status involves identifying a subject, the amyloidosis status of which is desired and obtaining a profile of drusen in a periphery of a retina of the subject. Another exemplary method of predicting an amyloidosis status involves analyzing a profile of drusen in a periphery of a retina of a subject to predict an amyloidosis status of the subject. Another exemplary method of predicting an amyloidosis status involves comparing a profile of drusen in a periphery of a retina of a subject to a control and predicting an amyloidosis status of the subject.