The present invention relates to improved ophthalmic solutions that employ a preservative enhancer chosen from the group consisting of dexpanthenol and panthenol and at least 0.00001 weight percent of a preservative, in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions. More particularly, a preferred ophthalmic solution comprises dexpanthenol, 0.2% of a phosphate buffer or Bis-Tris propane, and 0.00001% of polyhexamethylene biguanide, wherein the solution is made isotonic with sodium chloride.
