A medical dressing (1； 20) is disclosed, comprising a substrate (2) comprising a first chemical compound, said substrate having a first surface (4), wherein said medical dressing further comprises an adhesive layer (3) having a skin-facing surface (6) to adhere said medical dressing to a dermal surface, wherein at least a portion of said skin-facing surface comprises a coating (9) comprising a second chemical compound. Also disclosed is a method of manufacturing such a medical dressing.
