A surgical instrument for fastening tissue with a staple. The instrument includes a cartridge adapted for containing the staple. The cartridge includes a mechanism adapted to selectively advance the staple toward a forward end of the cartridge so the ends of the staple protrude from the cartridge and to selectively close the staple. The cartridge includes a mount connected to the cartridge and adapted for mounting the cartridge to an end of an endoscope. The cartridge includes a linkage connected to the cartridge for actuating the mechanism to advance and close the staple and a remote actuator connected to the linkage a predetermined distance from the cartridge for actuating the mechanism from a position remote from the cartridge.
