Ling-Jie Gao,Piet André Maurits Maria Herdewijn,Steven Cesar Alfons De Jonghe,William John Watkins,Lee Shun Chong
申请号：
US12374433
公开号：
US09259426B2
申请日:
2007.07.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This invention provides quinazoline derivatives represented by the structural formula: (I) wherein: R2 is hydrogen, NR′R″, C1-7 alkyl, arylC1-7 alkyl or C3-10 cycloalkyl R4 is amino, C1-7 alkyl, C2-7 alkenyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, aryl, heterocyclic, arylalkyl, heterocyclic-substituted C1-7 alkyl or C3-10 cycloalkyl-C1-7 alkyl R5 is hydrogen or C1-7 alkyl, or R5 and R4 together with the nitrogen atom to which they are attached form a heterocyclic ring Y is a single bond, C1-7 alkylene, C2-7 alkenylene or C2-7 alkynylene R6 is halogen, heteroaryl or aryl R′ and R″ are each independently hydrogen, C1-7 alkyl-carbonyl or C1-7 alkyl provided that R4 is not phenyl substituted with morpholino when R2 is H and R5 is H, and provided that when NR4R5 is piperazinyl, said NR4R5 is either non-substituted or substituted with methyl or acetyl a pharmaceutically acceptable addition salt, a stereoisomer, a mono- or a di-N-oxide, a solvate or a pro-drug thereof, for the treatment of viral infections.
