The present invention relates to an ultrasound assisted medical laser for the therapeutic and cosmetic treatment of a patients skin and underlying adipose tissue and more particularly, to apparatuses and methods using combinations of ultrasound, lasers and cryogenic energy to rejuvenate and condition skin and related tissue. The device of the present invention comprises a laser generator, an ultrasound generator, an ultrasound transducer, a handpiece containing a transducer tip at the distal end of the ultrasound transducer, and a laser tip. Ultrasonic and light radiation is directed into the tissue being treated. A cryogenic solution is circulated through the ultrasound tip to transfer thermal energy away from the tissue to preserve the tissue being treated by providing a synergistic effect with the ultrasonic radiation and light radiation.