用於治療發炎病症之新穎化合物及彼等之醫藥組合物农业专利-农业专业知识服务系统

发明人:: DESROY, NICOLAS,迪斯罗伊　尼可拉斯,迪斯羅伊　尼可拉斯,HECKMANN, BERTRAND,艾克曼　柏城恩,BRYS, REGINALD CHRISTOPHE XAVIER,布莱斯　瑞吉纳德　克里斯多夫　萨维尔,布萊斯　瑞吉納德　克里斯多夫　薩維爾,强库尔　艾内　玛莉,強庫爾　艾內　瑪莉,PEIXOTO, CHRISTOPHE,裴索图　克里斯多弗,裴索圖　克里斯多,迪斯罗伊尼可拉斯,迪斯羅伊尼可拉斯,艾克曼柏城恩,布莱斯瑞吉纳德克里斯多夫萨维尔,布萊斯瑞吉納德克里斯多夫薩維爾,强库尔艾内玛莉,強庫爾艾內瑪莉,裴索图克里斯多弗,裴索圖克里斯多

摘要：: The present invention discloses compounds according to Formula I:Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.本發明揭示根據式I之化合物：其中R1a、R1b、R2、R4、R5、R6a、R6b、R7、R8、W、X、Cy及下標a係如本文所定義。本發明係關於抑制自趨化素(NPP2或ENPP2)之化合物、其製造方法、包含其之醫藥組合物及使用其之治療方法，該等方法藉由投與本發明化合物來防治及/或治療涉及纖維變性疾病、增生性疾病、發炎性疾病、自體免疫疾病、呼吸道疾病、心血管疾病、神經退化性疾病、皮膚病症及/或異常血管生成相關疾病之疾病。